By R. Steiner (auth.), Dr. Rudolf Steiner, Dr. Paul B. Weisz, Dr. Robert Langer (eds.)
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Extra resources for Angiogenesis: Key Principles — Science — Technology — Medicine
However, since the endothelia involved in sprout formation differentiate very rapidly, only the cells at the tip of the sprout reveal their characteristic features: the endothelium becomes higher, and the slit-like lumina become more tighter. Depending on the stage of fusion, more or less distinctly pronounced cell contacts can be shown amongst the endothelia involved. Network formation The angiogenic activity mentioned results in a characteristic vascular architecture [2, 11], as studied by corrosion cast specimens.
Science 1973; 197: 443-447. 6 Glimelius B, Busch C, Hook M: Binding of Heparin on the surface of human endothelial cells. Throm Res 1978; 12: 773-782. 7 Barzu T, Molho P, Tobelem G, Petitou M, Caen J: Binding and endocytosis of heparin by human endothelial cells in culture. Biochim biophys Acta 1985; 196-203. 8 Barzu T, Van Rijn JLML, Petitou M, Molho P, Tobelem G, Caen JP: Endothelial binding sites for heparin: Biochem J 1986; 238: 847-854. 9 Weisz PB, Herrmann HC, Joullie MM, Kumor K, Levine E, Macarak EJ, Weiner D: Angiogenesis and GAG-Mimics: this book.
The importance of these fundamentals lie in the fact that while experimental results presented by individual groups undoubtedly reflect the truth of their experiments they cannot necessarily be extrapolated into broad generalizations. One fundamental point which was addressed was that although tumours consist of masses of heterogeneous cancer cells (most of which are dead, dying or doomed) the neovasculature which supplies them consists of cells which are essentially normal even if the blood vessels as a whole are not.