Antibiotics and Chemotherapy by Grüneberg MD

By Grüneberg MD

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Brit. Med. , 1, 653 44 Sapico, F. , Kegs, T. F. and Hewitt, W. L. (1972). Experimental enterococcal endocarditis. II. Study of in vivo synergism of penicillin and streptomycin. Am. J. Med. , 263, 128 45 Mandell, G. , Levison, M. E. and Hook, E. W. (1970). Enterococcal endocarditis: an analysis of 38 patients observed at the New York Hospital Cornell Medical Center. Arch. Intern. , 125,258 46 Geraci, J. E. and Martin, W. J. (1953). Antibiotic therapy of bacterial endocarditis. Circulation, 10, 173 47 Watanakunakorn, C.

Myers, B. R. and Weinstein, L. (1968). Treatment of bacterial endocarditis with cephalothin. N. Eng/. J. , 279, 1305 93 Fekety, F. R. and Weiss, P. (1966). Antibiotic synergism: Enhanced susceptibility of enterococci to combinations of streptomycin and penicillin or cephalosporins. Antimicrob. , 6, 156 94 Durack, D. , Starkebaum, M. , and Petersdorf, R. G. (1977). Chemotherapy of experimental streptococcal endocarditis. VI. Prevention of enterococcal endpcarditis. J. Lab. Clin. , 90, 171 95 Mandell, G.

Causative bacteria Prophylaxis is much more likely to be successful if one knows the bacteria, or at least the group of bacteria, that are likely to cause the infection that is to be prevented. Indeed, with this information it may be possible to preclude the necessity for prophylactic antibiotics altogether by taking measures that intercept the transmission of the organism to the site of inoculation. If prophylactic antibiotics do seem feasible, then an agent with the appropriate spectrum of activity can be selected.

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